© Nervous System: Immune complex deposition, antineuronal antibody activity leading to cerebritis, seizures, organic brain syndrome and peripheral neuropathies
© Integumentary System: Immune complex deposition, inflammation of dermal-epidermal junctions, vasculitis (fixed erythema, flat or raised over the malar eminences tending to spare nasolabial folds, erythematous atrophied plaques, scaling areas on the face, neck, and arms, petechiae, purpuric lesions, paleness)
© Musculoskeletal System: Increased fibrin deposits at synovial surfaces, inflammation of arterioles, venules and tendon sheaths; eventual necrosis, degeneration, and fibrosis of muscle tissue (joint pain and swelling, stiffness, limited movement, ulnar deviation of the second to fifth fingers and subluxation of the metacarpophalangeal (MCP) joints (Jaccoud’s arthropathy)
© Cardiovascular System: Diffuse vasculitis; inflammation and scarring of atrioventricular and sinoatrial nodes; inflammation of pericardial sac (high blood pressure)
© Respiratory System: pleural inflammation, pneumonitis, pulmonary hypertension
© Digestive System: collagen degeneration and vasculitis leading to mucous membrane ulcers; vasculitis leading to organ infarction and necrosis
© Urinary System: Deposition of immune complexes in glomerular basement membranes (resulting to edema, proteinuria, hypertension, flank pain)
Source: Black, Joyce. Et al. (2008). Medical Surgical Nursing (8th Ed.) J.B. Lippincott Company.
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